UltraFade
DESCRIPTION
Skin lightening formulations continue to gain in popularity. Consumers are looking for products that target irregular hyper pigmentation, freckles, age spots and melasma for evening out skin tones and creating a lighter, brighter, more radiant complexion. While hydroquinone is the most recognized skin lightening ingredient and considered the benchmark for measuring skin whitening abilities, it does have its drawbacks and is banned in a number of countries for use in cosmetics.
UltraFade™ has been clinically proven to provide the answer in the search for a natural alternative to hydroquinone for skin lightening and the creating of a more youthful skin tone. In studies, UltraFade™ outperformed Kojic Acid and Vitamin C esthers. More importantly, UltraFade™ was proven to out perform hydroquinone.
Tyrosinase is an enzyme that is responsible for the production of melanin. This revolutionary new peptide takes a triple action approach by combining the oxygenation and cell turn-over benefits from yeast with a proven tyrosinase inhibitor with a natural polymer infrastructure to enhance stability and efficacy. The end result is technology that inhibits the production and appearance of the pigmentation, while accelerating the renewal of skin cells to degrade the existing concentration of melanin in the dermis.
Key Benefits
- Natural alternative for skin lightening and brightening systems
- Proven to outperform kojic acid and hydroquinone as a tyrosinase inhibitor
- Gently stimulate skin cell turnover
- Visibly lightens skin and evens out skin tones
- Enhanced with antioxidant activity to enhance the overall younger appearance
EFFICACY
Skin Whitening Study
The goal is to find the optimum ingredient for inhibiting tyrosinase. The enzymatic activity is measured by a colormetric method and the concentration of test material required to inhibit the enzyme by fifty percent is determined (IC50). The lower the IC50 the more effective the inhibitor.
Test Material IC50
Hydroquinone 0.0015
Kojic Acid 0.0025
Ascorbic Acid 0.0400
Ascorbyl Palmitate No Effect
Magnesium Ascorbyl
Phosphate No Effect
UltraFade™ 0.0007
Cell Renewal Activity
The cell renewal activity was
studied with the standard dansyl chloride technique.
Two test concentrations, 3% and 5%, were applied
to the volar forearms of the test subjects twice
daily for the duration of the study and then compared
to an untreated site of the forearm. Twelve test
subjects, ages 30 to 55, demonstrated an increase
in cell renewal rates by 17% and 27% respectively.
Cell Renewal Study
|
Untreated |
3% of Material
|
5% of Material |
Subject |
(Days*) |
(Days) |
(Days) |
#1 |
14 |
11.04 |
9.14 |
#2 |
17 |
12.00 |
10.85 |
#3 |
10 |
7.03 |
6.02 |
#4 |
21 |
16.50 |
14.65 |
#5 |
17 |
15.05 |
13.12 |
#6 |
10 |
9.00 |
7.85 |
#7 |
12 |
10.00 |
9.10 |
#8 |
17 |
14.05 |
13.15 |
#9 |
19 |
16.50 |
15.80 |
#10 |
13 |
12.01 |
10.90 |
#11 |
8 |
7.02 |
6.78 |
#12 |
17 |
15.00 |
13.55 |
AVERAGES |
14.58 |
12.10 |
10.91 |
% INCREASE IN CELL TURNOVER
|
|
| 17.01%
|
25.18%
*Days required for cellular
renewal |
Summary
While ascorbic acid showed significant results, the esthers of ascorbic acid (Ascorbyl Palmitate and Magnesium Ascorbyl Phosphate) demonstrated no effect. Even more interesting was that by protecting and enhancing the delivery of the ascrobic acid with the natural polymer infrastructure, UltraFade™ was able to demonstrate that it was twice as potent as hydroquinone…providing a natural alternative for skin whitening.
UltraFade™ is recommended for usage in:
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